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ePub Death Receptors in Cancer Therapy (Cancer Drug Discovery and Development) download

by Wafik S. El-Deiry

ePub Death Receptors in Cancer Therapy (Cancer Drug Discovery and Development) download
Author:
Wafik S. El-Deiry
ISBN13:
978-1588291721
ISBN:
1588291723
Language:
Publisher:
Humana Press; 2005 edition (December 3, 2004)
Category:
Subcategory:
Medicine & Health Sciences
ePub file:
1547 kb
Fb2 file:
1160 kb
Other formats:
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Rating:
4.1
Votes:
711

on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers.

Cancer Drug Discovery and Development. Death Receptors in Cancer Therapy. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer.

field of anticancer drug discovery. Yan Zhang, ChemMedChem, Vol. 5, 2010). Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor.

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by Wafik S. El-Deiry. Published December 3, 2004 by Humana Press Immunology, Methods, Cancer, Molecular aspects, Apoptosis, Neoplasms, Gene Therapy, Cell Death, Tumor Necrosis Factor Receptors, Cell. Published December 3, 2004 by Humana Press. Immunology, Methods, Cancer, Molecular aspects, Apoptosis, Neoplasms, Gene Therapy, Cell Death, Tumor Necrosis Factor Receptors, Cell receptors, Cellular signal transduction, Therapy.

Автор: El-Deiry Название: Death Receptors in Cancer Therapy Издательство: Springer .

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.