ePub Biomedical Significance of Nitric Oxide download

by George B. Stefano

Author:

George B. Stefano

ISBN13:

978-8390923147

ISBN:

8390923149

Publisher:

Medical Science International (October 2003)

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1731 kb

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Nitric oxide and its biomedical significance. The invention relates to nitric oxide (NO) stimulating extracts from various plants.

Nitric oxide and its biomedical significance. Such extracts contain compounds known as healthin I and healthin II. Specifically, the invention provides partially purified plant extracts that have NO stimulating activity, methods of isolating and partially purifying such extracts from plant materials.

STEFANO, George, B. ZHU, Wei MANTIONE, Kirk KREAM, Richard, M. Title: Nitric oxide and its biomedical significance

STEFANO, George, B. Title: Nitric oxide and its biomedical significance. Abstract: A pharmaceutical composition for stimulating nitric oxide production in mammalian cells, the pharmaceutical composition including at least one compound selected from a group consisting of: 2,3-dihydroxypropyl oleate; bis(m-phenoxyphenyl) ether; 6-acetyl-5,6,6a,zo(de,g)quinoline; and (+)-N-(p-(2-methylbutoxy)benzylidene)-4

Author of Biomedical Significance of Nitric Oxide, CRC Handbook of Comparative Opioid and Related Neuropeptide Mechanisms Volume I, Musical .

Author of Biomedical Significance of Nitric Oxide, CRC Handbook of Comparative Opioid and Related Neuropeptide Mechanisms Volume I, Musical Healing. Created April 29, 2008.

Biomedical Significance of Homocysteine 9. 10 Kilmer McCully. mocysteine reacts with nitric oxide to preve nt the relaxing effect of this chemi-. cal medi at or on smoot h musc le tone. mocysteine levels cause arteriosclerotic plaques, regardless of which enzyme. Publicity surrounding the publication of these books, the. major clinical and epidemiological studies, and marketing of B vitamin sup-. Hyperhomocys teinemia causes endothe

Описание: Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges . Описание: Presents information on nitrosothiols and nitric oxide in cell signaling. This book details nitric oxide and mitochondrial functions.

Описание: Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology.

The instability and low concentration of nitric oxide (NO) in specimens make it difficult to be detected directly. In this chapter, a method for imaging nitric oxide using laser scanning confocal microscopy (LSCM) is presented. A cultured hippocampal neuron is dyed with DAF-2 and observed under a Zeiss LSM 510 laser scanning confocal microscope.

Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching. Detection of nitric oxide in exhaled human breath: exercise and resting determinations. Authors: Kirk J Mantione Tobias Esch George B Stefano.

Are you George B Stefano? Register this Author. Register with ORCID iD. PUBLICATIONS 100. George B Stefano. About publications (100) network. Publications by authors named "George B Stefano". Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching. Authors: George B Stefano Christopher Snyder Richard M Kream.

Nitric oxide (nitrogen oxide, nitrogen monoxide) is a molecular, chemical compound with chemical formula of · N. .Low levels of nitric oxide production are important in protecting organs such as the liver from ischemic damage.

Nitric oxide (nitrogen oxide, nitrogen monoxide) is a molecular, chemical compound with chemical formula of · N O. One of several oxides of nitrogen, it is a colorless gas under standard conditions. Nitric oxide is a free radical-i. its bonding structure includes an unpaired electron, represented by the dot (·) on the nitrogen atom-and it is in the class of heteronuclear diatomic molecules that are of historic theoretical interest (for the insights they gave in formulating early modern theories of bonding).

Special emphasis is placed on the biological chemistry, physiology, pharmacology, enzymology and pathological significance of these molecules in human health and disease. The journal also accepts manuscripts relating to plant and microbial studies involving these molecules.

Biological functions of nitric oxide. Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of NO. In mammals including humans, nitric oxide is a signaling molecule involved in many physiological and pathological processes. It is a powerful vasodilator with a half-life of a few seconds in the blood. Standard pharmaceuticals such as nitroglycerine and amyl nitrite are precursors to nitric oxide

In 1998, the Nobel Prize in Physiology was awarded to Drs. Furchgott, Murad and Ignarro for their work on nitric oxide. For the past 20 years,since the work began on nitric oxide, the importance of its interactions in biochemistry, physiology and pathology has been steadily increasing. Nitric oxide’s role as an intercellular and intracellular signaling substance has been essential in further understanding its significance. Its first discovered action as a vasodilator, working via guanylate cyclase, set the stage for uncovering other mechanisms of action. Its involvement in the central nervous system is important. Its role as a free radical and free radical scavenger, depending on the microenvironmental circumstances, is equally noteworthy. Its ability to exert anti-viral and anti-bacterial activities further enhances its value in living organisms. In this regard, since nitric oxide has the potential to be toxic, however, it is inert when it is present with most biological substances, a property that may be vital in focusing its actions on specific molecules. Its actions occur in seconds, and during this time it can diffuse over 50 µM. Its main route of destruction appears to be via hemoglobin or myoglobin, forming nitrate.

In general, most signal molecules work via conformational matching with a complementary receptor. Nitric oxide appears to work via modulating its concentration in a particular microenvironment. In this regard, the presence of nitric oxide synthase (NOS) isoforms is critical to this modulation. As the name implies, constitutive NOS produces basal levels of nitric oxide that can be enhanced when called for by physical means, i.e, mechanotransduction in blood vessels, and/or classical signaling molecules coupled to constitutive NOS activation, i.e, acetylcholine. If higher and/or sustained levels of nitric oxide are called for, as in a strong proinflammatory response, inducible NOS, after a latent period, emerges. In all, for such a small, simple gas molecule,its actions are diverse and complex. Its relevance in biological systems is further highlighted by finding it performing the same functions in invertebrates, implying that it has a long evolutionary history and was necessary in this evolvement as well.

This text focuses attention on many of the above mentioned phenomena associated with nitric oxide signaling. It further focuses attention on the basal level of nitric oxide and its implications. Nitric oxide levels measured in real time, via nitric oxide probes, have revealed that basal levels of this gas are present and controlling physiological states of cellular activation. This, in itself, opens another key avenue of nitric oxide research with clinical relevance since it expands our understanding of the basic functioning of different organ systems. In this regard, we are still just beginning to comprehend the significance of nitric oxide in living systems, as well as in understanding various pathologies.

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